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Weight loss poses a huge challenge for most people who attempt it.

What role, if any, does a person’s gut microbiome play in how easy or difficult it can be to lose weight?

A recent study looked at the microbiomes of people who lost weight and compared them to the microbiomes of people who did not lose weight . . . and researchers found some interesting links!

People who were able to lose weight had more microbes that grew faster and produced anti-inflammatory compounds, while those who did not lose weight had more microbes that produced the enzyme amylase that breaks starches into sugars.

Introducing a done-for-you pre-written Health scoop (new study update) to share this information with your clients and patients along with a few practical tips.

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Product Details:

Document Type: MS Word

Release Date: November 2021

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This Health scoop (new study update) was created to help you consistently stay in touch with your email subscribers while keeping you up-to-date with some of the most fascinating recent studies and includes:

  • A short primer for your clients on the gut microbiome and that weight is influenced by so many factors

  • How this study found several differences in gut microbiomes between people who lost weight and those who did not
  • A few tips on how to nurture a healthy gut microbiome (more clinical research is needed before we can develop or recommend probiotics for weight loss)

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Easy-to-understand study summary with some practical strategies and tips for your clients

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Diener, C., Qin, S., Zhou, Y., Patwardhan, S., Tang, L., Lovejoy, J. C., Magis, A. T., Price, N. D., Hood, L., & Gibbons, S. M. (2021). Baseline Gut Metagenomic Functional Gene Signature Associated with Variable Weight Loss Responses following a Healthy Lifestyle Intervention in Humans. mSystems, 6(5), e0096421. https://doi.org/10.1128/mSystems.00964-21
https://journals.asm.org/doi/10.1128/mSystems.00964-21
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8547453/

About the study:

  • Microbe = one microscopic organism, like a bacterium, or yeast
  • Microbiota = a community of different microbes living together
  • Microbiome = the genes included in a microbiota
  • Conclusion: “Overall, our results suggest that the microbiota may influence host weight loss responses through variable bacterial growth rates, dietary energy harvest efficiency, and immunomodulation.”
  • “These findings…may help optimize the weight-loss protocols in future studies.”
  • The researchers say that it is still too soon to be able to engineer your gut microbiome. 
  • There are currently no probiotics or other treatments that we can recommend, but research is progressing and this may become an option one day in the future.
  • Note that all studies have limitations. That’s why it’s important to look at multiple studies, giving more weight to the ones that have a better design to answer the questions being asked. For this one, the researchers enrolled participants into a year-long behavioural coaching program to try to help them lose weight. They took stool samples and other metrics (e.g., blood samples). The final sub-cohort ended up with 15 participants who lost the most weight and 10 who did not lose weight.
  • This means it’s not a randomized control trial as participants were not randomized into an “intervention” or “control/placebo” arm (which would be even better). 
  • Study strength is rated a 5.5/7 according to this chart (better than a cohort, but not as good as an RCT): https://www.compoundchem.com/2015/04/09/scientific-evidence/ 

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Customizable health study summary with practical tips

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Related topics: Gut microbiome, weight, nutrition

Backgrounder articles: Links to 3 backgrounder articles

Study design: Participants enrolled into a year-long behavioural coaching program to try to help them lose weight. They provided stool samples and other metrics (e.g., blood samples). The final sub-cohort ended up with 15 participants who lost the most weight and 10 who did not lose weight. The microbiomes of these two groups were compared.

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Price (until Mon, Nov 29): US$37 $27

Easy-to-understand study summary with some practical strategies and tips for your clients

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This Health scoop has natural links to:

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3,787 words in 2 parts – 27 references

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